| Primary Identifier | MGI:107543 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 20671 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Enables DNA-binding transcription activator activity, RNA polymerase II-specific; beta-catenin binding activity; and transcription cis-regulatory region binding activity. Involved in several processes, including endodermal cell fate specification; endodermal digestive tract morphogenesis; and heart morphogenesis. Acts upstream of or within several processes, including circulatory system development; embryonic morphogenesis; and hepaticobiliary system development. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; egg cylinder; and genitourinary system. Used to study biliary atresia. Human ortholog(s) of this gene implicated in intracranial aneurysm; patent ductus arteriosus; and vesicoureteral reflux. Orthologous to human SOX17 (SRY-box transcription factor 17). PHENOTYPE: Embryos homozygous for a targeted null mutation develop a deficient gut endoderm and die around embryonic day 10.5. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
