| Primary Identifier | MGI:98731 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 21817 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables protein-glutamine gamma-glutamyltransferase activity. Involved in intracellular calcium ion homeostasis; positive regulation of cell adhesion; and regulation of apoptotic cell clearance. Acts upstream of or within branching involved in salivary gland morphogenesis and salivary gland cavitation. Located in collagen-containing extracellular matrix. Is expressed in several structures, including alimentary system; bone; central nervous system; genitourinary system; and sensory organ. Used to study maturity-onset diabetes of the young. Orthologous to human TGM2 (transglutaminase 2). PHENOTYPE: A homozygous null mutation causes alterations in glucose and aerobic energy metabolism, tumor growth, and response to myocardial infarction, liver injury, and LPS-induced sepsis. A second null mutation confers resistance to renal injury, while a third one alters cell adhesion and T cell physiology. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
