| Primary Identifier | MGI:97615 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 18803 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables glutamate receptor binding activity; phosphatidylinositol phospholipase C activity; and receptor tyrosine kinase binding activity. Involved in modulation of chemical synaptic transmission. Acts upstream of or within T cell receptor signaling pathway and in utero embryonic development. Located in cell-cell junction. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and integumental system. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and lung non-small cell carcinoma. Orthologous to human PLCG1 (phospholipase C gamma 1). PHENOTYPE: Mice homozygous for a knock-out allele exhibit early embryonic lethality associated with arrested growth and/or abnormal hematopoiesis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
