Primary Identifier | MGI:1891917 | Organism | mouse, laboratory |
Chromosome | 2 | NCBI Gene Number | 54401 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables protein domain specific binding activity. Acts upstream of or within protein targeting. Predicted to be located in cytosol and perinuclear region of cytoplasm. Predicted to be part of transcription repressor complex. Predicted to be active in cytoplasm. Is expressed in several structures, including genitourinary system; nervous system; palatal shelf; retina layer; and thymus. Orthologous to human YWHAB (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta). PHENOTYPE: Mice homozygous for a conditional allele activated in hepatocytes exhibit decreased liver glycogen levels, impaired glucose tolerance after pyruvate injection, and enhanced gluconeogenesis. [provided by MGI curators] |