| Primary Identifier | MGI:109297 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 20568 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables endopeptidase inhibitor activity. Involved in antibacterial humoral response; innate immune response; and response to lipopolysaccharide. Located in extracellular space. Is expressed in embryo; liver left lobe; liver right lobe; and ureter. Orthologous to human SLPI (secretory leukocyte peptidase inhibitor). PHENOTYPE: Homozygous null mice been independently reported to exhibit increased susceptibility to LPS-induced endotoxin shock with elevated production of IL-6, impaired cutaneous wound healing with increased inflammation and elastase activity, and high susceptibility to pulmonary mycobacterial infection. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
