| Primary Identifier | MGI:1276535 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 17979 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II complex binding activity; and transcription coactivator activity. Involved in cell dedifferentiation and positive regulation of stem cell population maintenance. Acts upstream of or within several processes, including labyrinthine layer morphogenesis; mammary gland branching involved in thelarche; and negative regulation of stem cell differentiation. Located in nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including 2-cell stage conceptus; 4-8 cell stage conceptus; central nervous system; genitourinary system; and hemolymphoid system. Human ortholog(s) of this gene implicated in obesity. Orthologous to human NCOA3 (nuclear receptor coactivator 3). PHENOTYPE: Nullizygous mice exhibit growth defects and reduced serum IGF-1 levels and may show impaired proliferative responses to various factors, delayed mammary gland growth and puberty, reproductive dysfunction, susceptibility to endotoxin shock, altered lymphopoiesis, and protection against obesity. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
