| Primary Identifier | MGI:1919293 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 72043 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables N-acetylglucosamine-6-sulfatase activity. Involved in several processes, including esophagus smooth muscle contraction; glomerular filtration; and skeletal system development. Acts upstream of or within several processes, including liver regeneration; positive regulation of canonical Wnt signaling pathway; and regulation of hepatocyte proliferation. Located in plasma membrane. Is expressed in several structures, including central nervous system; embryo mesenchyme; genitourinary system; limb; and sensory organ. Orthologous to human SULF2 (sulfatase 2). PHENOTYPE: Homozygous disruption of this gene may lead to a partially penetrant, strain-dependent phenotype of embryonic lethality, reduced postnatal body weight, lung abnormalities, brain malformations, and reduced fertility. Mice homozygous for a hypomorphic gene-trap allele display skeletal defects. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
