| Primary Identifier | MGI:96666 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 16500 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables delayed rectifier potassium channel activity. Involved in several processes, including cellular response to glucose stimulus; negative regulation of insulin secretion; and positive regulation of long-term synaptic depression. Located in dendrite and neuronal cell body membrane. Part of voltage-gated potassium channel complex. Is expressed in several structures, including adipose tissue; brain; cardiovascular system; genitourinary system; and gut. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 26 and epilepsy. Orthologous to human KCNB1 (potassium voltage-gated channel subfamily B member 1). PHENOTYPE: Mice homozygous for a null allele show reduced fasting glucose levels, hyperinsulinemia, improved glucose tolerance, and enhanced insulin secretion. Mice homozygous for another null allele exhibit loss of photoreceptors with increased apoptosis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
