| Primary Identifier | MGI:2146885 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 263876 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable signaling receptor complex adaptor activity and ubiquitin-specific protease binding activity. Involved in protein linear deubiquitination; regulation of necroptotic process; and regulation of tumor necrosis factor-mediated signaling pathway. Acts upstream of or within seminiferous tubule development and spermatogenesis. Located in cytoplasm. Is expressed in several structures, including alimentary system; eye; genitourinary system; immune system; and nervous system. Orthologous to human SPATA2 (spermatogenesis associated 2). PHENOTYPE: Homozygous knockout leads to small testes, oligospermia, asthenozoospermia, reduced male fertility and decreased male germ cell numbers. It also affects necroptosis and increases inflammatory responses. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
