| Primary Identifier | MGI:2685408 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 228913 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within cellular senescence. Predicted to be located in mitochondrion and nuclear speck. Predicted to be part of histone deacetylase complex. Predicted to be active in nucleus. Is expressed in central nervous system; genitourinary system; paraxial mesenchyme; and tail. Orthologous to human ZNF217 (zinc finger protein 217). PHENOTYPE: Knock-out mice show prenatal lethality. Heterozygotes are resistant to high-fat diet-induced obesity, have smaller adipocytes, improved glucose tolerance and insulin sensitivity, and increased energy expenditure on this diet. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
