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Protein Coding Gene : Spo11 SPO11 initiator of meiotic double stranded breaks
Primary Identifier  MGI:1349669 Organism  mouse, laboratory
Chromosome  2 NCBI Gene Number  26972
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Predicted to enable DNA binding activity. Acts upstream of or within several processes, including germ cell development; meiosis I; and ovarian follicle development. Located in chromosome, telomeric region. Is expressed in several structures, including genitourinary system; hemolymphoid system gland; liver; oral epithelium; and skin. Orthologous to human SPO11 (SPO11 initiator of meiotic double strand breaks).
PHENOTYPE: Homozygous knockout affects double-stranded breaks in male meiosis causing loss of spermatocytes in early prophase and sterility, while mutant females exhibit oocyte loss soon after birth. [provided by MGI curators]
  • synonyms:
  • Spo11a,
  • AI449549,
  • expressed sequence AI449549,
  • Spo11,
  • MGI:2138956,
  • SPO11 initiator of meiotic double stranded breaks,
  • Spo11b
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