| Primary Identifier | MGI:97501 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 18534 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables phosphoenolpyruvate carboxykinase (GTP) activity. Involved in several processes, including gluconeogenesis; glyceraldehyde-3-phosphate biosynthetic process; and positive regulation of memory T cell differentiation. Acts upstream of or within several processes, including cellular response to potassium ion starvation; glycerol biosynthetic process from pyruvate; and positive regulation of transcription by RNA polymerase II. Is active in cytosol. Is expressed in several structures, including alimentary system; brown fat; cerebral cortex; liver; and urinary system. Human ortholog(s) of this gene implicated in Alzheimer's disease and type 2 diabetes mellitus. Orthologous to human PCK1 (phosphoenolpyruvate carboxykinase 1). PHENOTYPE: Mice homozygous for a null allele exhibit early postnatal lethality, decreased body fat, decreased glycogen levels in the liver, and altered blood chemistry. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
