Primary Identifier | MGI:2672878 | Organism | mouse, laboratory |
Chromosome | 2 | NCBI Gene Number | 277353 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Located in male germ cell nucleus. Is expressed in brain and testis. Orthologous to human TCFL5 (transcription factor like 5). PHENOTYPE: Mice homozygous for a knock-out allele exhibit male sterility associated with small testis size, azoospermia, multinucleated giant male germ cells, arrest of male meiosis in a diplotene like stage, and increased male germ cell apoptosis. [provided by MGI curators] |