| Primary Identifier | MGI:2153710 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 140489 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and E-box binding activity. Acts upstream of or within eye morphogenesis; negative regulation of retinal cell programmed cell death; and positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including brain; branchial arch; limb; maxillary process; and urinary system. Orthologous to human BHLHE23 (basic helix-loop-helix family member e23). PHENOTYPE: Mice homozygous for a knock-out allele display a severe deficit in retinal activity characterized by improper retinal rod bipolar cell maturation, loss of the scotopic ERG b-wave, and a significant increase in inner nuclear layer (INL) cell apoptosis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
