Primary Identifier | MGI:1917431 | Organism | mouse, laboratory |
Chromosome | 2 | NCBI Gene Number | 228994 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables N6-methyladenosine-containing RNA reader activity. Involved in several processes, including learning or memory; post-transcriptional regulation of gene expression; and regulation of long-term synaptic potentiation. Located in cytoplasm. Is expressed in brain; future spinal cord; intestine; liver; and spinal cord. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human YTHDF1 (YTH N6-methyladenosine RNA binding protein F1). PHENOTYPE: Mice homozygous for a knock-out allele exhibit learning and memory defects as well as impaired hippocampal synaptic transmission and long-term potentiation. [provided by MGI curators] |