| Primary Identifier | MGI:2385169 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 229003 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable RNA binding activity; RNA helicase activity; and exoribonuclease II activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II and regulatory ncRNA-mediated post-transcriptional gene silencing. Predicted to be located in cytoplasm. Predicted to be active in P granule and cytosol. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; respiratory system; and telencephalon. Orthologous to human HELZ2 (helicase with zinc finger 2). PHENOTYPE: Mice homozygous for a knock-out allele exhibit slower weight gain, hyperleptinemia, increased oxygen consumption, decreased respiratory quotient, decreased liver triglyceride level and ameliorated hyperlipidemia and hepatosteatosis when fed a high-fat diet. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
