| Primary Identifier | MGI:101790 | Organism | mouse, laboratory |
| Chromosome | 3 | NCBI Gene Number | 16592 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables retinoic acid binding activity. Involved in several processes, including positive regulation of cold-induced thermogenesis; positive regulation of peroxisome proliferator activated receptor signaling pathway; and regulation of retrograde trans-synaptic signaling by endocanabinoid. Acts upstream of or within several processes, including glucose homeostasis; negative regulation of D-glucose transmembrane transport; and phosphatidylcholine biosynthetic process. Located in several cellular components, including extracellular space; nucleus; and postsynaptic density. Is active in glutamatergic synapse; postsynaptic cytosol; and postsynaptic density, intracellular component. Is expressed in several structures, including central nervous system; jaw; long bone; retina; and skin. Orthologous to several human genes including FABP5 (fatty acid binding protein 5). PHENOTYPE: Mice homozygous for disruptions in this gene, depending on allele, display impaired skin barrier function or resistance to diet-induced obesity, showing decreased adipose tissue and imporved glucose tolerance and insulin sensitivity. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
