| Primary Identifier | MGI:88038 | Organism | mouse, laboratory |
| Chromosome | 3 | NCBI Gene Number | 11770 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables hormone receptor binding activity; long-chain fatty acid binding activity; and long-chain fatty acid transmembrane transporter activity. Involved in long-chain fatty acid transport and positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including brown fat cell differentiation; cellular response to lithium ion; and negative regulation of macromolecule metabolic process. Located in cytoplasm and nucleus. Is expressed in several structures, including adipose tissue; central nervous system; gut; heart; and integumental system. Orthologous to human FABP4 (fatty acid binding protein 4). PHENOTYPE: Homozygotes for a targeted null mutation exhibit susceptibility to diet-induced obesity, attenuated dibutyryl cAMP-induced adipocyte release of glycerol and free fatty acid, and reduced acute insulin secretion in response to beta-adrenergic stimulation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
