| Primary Identifier | MGI:87965 | Organism | mouse, laboratory |
| Chromosome | 3 | NCBI Gene Number | 11608 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable angiotensin receptor activity; bradykinin receptor binding activity; and protein heterodimerization activity. Involved in regulation of blood pressure. Acts upstream of or within several processes, including blood vessel development; drinking behavior; and regulation of systemic arterial blood pressure by circulatory renin-angiotensin. Predicted to be active in plasma membrane. Is expressed in several structures, including adrenal gland; genitourinary system; heart; liver; and lung. Human ortholog(s) of this gene implicated in several diseases, including COVID-19; artery disease (multiple); chronic kidney disease; neurodegenerative disease (multiple); and sarcoidosis. Orthologous to human AGTR1 (angiotensin II receptor type 1). PHENOTYPE: Homozygotes for targeted null mutations are phenotypically normal, but homozygotes for the Agtr1b/Agtr1a double knockout exhibit reductions in growth, survival, blood pressure, and kidney size not found in either single knockout. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
