| Primary Identifier | MGI:109585 | Organism | mouse, laboratory |
| Chromosome | 3 | NCBI Gene Number | 18805 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable phospholipase D activity. Acts upstream of or within defense response to Gram-positive bacterium. Predicted to be located in several cellular components, including Golgi cisterna; cytoplasmic vesicle; and lamellipodium. Predicted to be active in cholinergic synapse; cytoplasmic vesicle; and plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in developmental cardiac valvular defect. Orthologous to human PLD1 (phospholipase D1). PHENOTYPE: Homozygotes for a null allele show reduced tumor growth and angiogenesis. Homozygotes for a second null allele show abnormal hepatic autophagy after food restriction. Homozygotes for a third null allele show altered platelet activation and protection from thrombosis and ischemic brain injury. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
