| Primary Identifier | MGI:106203 | Organism | mouse, laboratory |
| Chromosome | 3 | NCBI Gene Number | 20482 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables chromatin binding activity. Acts upstream of or within several processes, including negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of apoptotic signaling pathway; and transforming growth factor beta receptor signaling pathway. Located in nucleus. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; musculoskeletal system; and sensory organ. Orthologous to human SKIL (SKI like proto-oncogene). PHENOTYPE: Heterozygotes for a null allele develop lymphomas and show increased incidence of chemically-induced tumors while homozygotes die before implantation. Homozygotes for a different null allele are viable but show defective T cell activation and impaired mammary gland alveologenesis and lactogenesis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
