Primary Identifier | MGI:106008 | Organism | mouse, laboratory |
Chromosome | 3 | NCBI Gene Number | 11747 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables phosphatidylserine binding activity. Predicted to be involved in several processes, including cellular response to gonadotropin-releasing hormone; negative regulation of prolactin secretion; and regulation of flagellated sperm motility. Located in endothelial microparticle and external side of plasma membrane. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and limb. Human ortholog(s) of this gene implicated in autoimmune disease of the nervous system; myocardial infarction; and systemic scleroderma. Orthologous to human ANXA5 (annexin A5). PHENOTYPE: Homozygous null mice are viable, fertile, and develop normally. Bone development and maintenance are normal, as are clinical-chemical parameters. [provided by MGI curators] |