| Primary Identifier | MGI:95516 | Organism | mouse, laboratory |
| Chromosome | 3 | NCBI Gene Number | 14173 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables growth factor activity. Involved in positive regulation of ERK1 and ERK2 cascade; positive regulation of protein phosphorylation; and stem cell development. Acts upstream of or within several processes, including nervous system development; positive regulation of cell differentiation; and positive regulation of cell population proliferation. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; extraembryonic component; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including Parkinsonism; corneal neovascularization; diabetic neuropathy; gastric ulcer; and impotence. Orthologous to human FGF2 (fibroblast growth factor 2). PHENOTYPE: Homozygotes for different null mutations are viable and have some or all of these traits: hypotension, thrombocytosis, impaired wound healing, and reductions in cortical neuronal density, vascular smooth muscle contractility and trabecular bone formation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
