| Primary Identifier | MGI:1345139 | Organism | mouse, laboratory |
| Chromosome | 3 | NCBI Gene Number | 24063 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Involved in negative regulation of cell differentiation and negative regulation of signal transduction. Acts upstream of or within several processes, including bud elongation involved in lung branching; kidney development; and negative regulation of signal transduction. Predicted to be located in Golgi apparatus and nucleoplasm. Predicted to be active in cytosol. Is expressed in several structures, including branchial arch; embryo ectoderm; integumental system; limb; and sensory organ. Orthologous to human SPRY1 (sprouty RTK signaling antagonist 1). PHENOTYPE: Homozygous null mice display postnatal lethality, premature death, abnormal kidney morphology and development with multiple ectopic ureteric buds, multiple ureters, and hydroureter. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
