| Primary Identifier | MGI:101783 | Organism | mouse, laboratory |
| Chromosome | 3 | NCBI Gene Number | 20873 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables identical protein binding activity and protein serine/threonine kinase activity. Involved in centriole replication; de novo centriole assembly involved in multi-ciliated epithelial cell differentiation; and trophoblast giant cell differentiation. Located in XY body; deuterosome; and nucleolus. Is expressed in several structures, including adrenal gland; alimentary system; brain; genitourinary system; and musculoskeletal system. Human ortholog(s) of this gene implicated in microcephaly and chorioretinopathy 2. Orthologous to human PLK4 (polo like kinase 4). PHENOTYPE: Mice homozygous for disruptions of this gene die before birth. Development is arrested around E7.5. Mice heterozygous for an ENU-induced allele or gene trap alele exhibit male hypogonadism. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
