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Protein Coding Gene : Unc80 unc-80, NALCN activator
Primary Identifier  MGI:2652882 Organism  mouse, laboratory
Chromosome  1 NCBI Gene Number  329178
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0)

Predicted to enable monoatomic cation channel activity. Predicted to be involved in monoatomic cation homeostasis; regulation of neuronal action potential; and sodium ion transmembrane transport. Part of sodium channel complex. Orthologous to human UNC80 (unc-80 subunit of NALCN channel complex).
PHENOTYPE: Mice homozygous for a null allele die within 24 hours of birth, exhibit severe apnea and hippocampal neurons show decreased NALCN-dependent sodium leak current. [provided by MGI curators]
  • synonyms:
  • BC042720,
  • C230061B10Rik,
  • MGI:2445028,
  • Unc80,
  • unc-80, NALCN activator,
  • C030018G13Rik,
  • RIKEN cDNA C230061B10 gene,
  • cDNA sequence BC042720,
  • RIKEN cDNA C030018G13 gene,
  • MGI:1925858
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2 Involved In Mutations

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3 Pathways

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Phenotype

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Disease

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