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Protein Coding Gene : Unc80 unc-80, NALCN activator
Primary Identifier  MGI:2652882 Organism  mouse, laboratory
Chromosome  1 NCBI Gene Number  329178
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0)

Predicted to enable monoatomic cation channel activity. Predicted to be involved in monoatomic cation homeostasis; regulation of neuronal action potential; and sodium ion transmembrane transport. Part of sodium channel complex. Orthologous to human UNC80 (unc-80 subunit of NALCN channel complex).
PHENOTYPE: Mice homozygous for a null allele die within 24 hours of birth, exhibit severe apnea and hippocampal neurons show decreased NALCN-dependent sodium leak current. [provided by MGI curators]
  • synonyms:
  • BC042720,
  • C230061B10Rik,
  • MGI:2445028,
  • Unc80,
  • unc-80, NALCN activator,
  • C030018G13Rik,
  • RIKEN cDNA C230061B10 gene,
  • cDNA sequence BC042720,
  • RIKEN cDNA C030018G13 gene,
  • MGI:1925858
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Features --> Cross References

Genome

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2 Involved In Mutations

Trail: ProteinCodingGene

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Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

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Function

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Homology

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Interactions

3 Pathways

Trail: ProteinCodingGene

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Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

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