| Primary Identifier | MGI:1920501 | Organism | mouse, laboratory |
| Chromosome | 3 | NCBI Gene Number | 73251 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables protein-lysine N-methyltransferase activity. Involved in peptidyl-lysine methylation. Acts upstream of or within heterochromatin organization. Predicted to be located in nucleolus. Predicted to be active in chromosome and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; musculature; and nervous system. Orthologous to human SETD7 (SET domain containing 7, histone lysine methyltransferase). PHENOTYPE: Homozygotes for a knock-out allele exhibit partial prenatal lethality and failure of mouse embryonic fibroblasts and spleen cells to arrest after doxorubicin treatment. Homozygotes for a different knock-out allele show resistance to bleomycin- or adenovirus-TGFbeta-induced pulmonary fibrosis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
