| Primary Identifier | MGI:1921684 | Organism | mouse, laboratory |
| Chromosome | 3 | NCBI Gene Number | 74434 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and protein dimerization activity. Involved in oocyte differentiation; positive regulation of transcription by RNA polymerase II; and spermatogenesis. Acts upstream of or within primary ovarian follicle growth and regulation of gene expression. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; gut; and liver. Orthologous to human CCDC169-SOHLH2 (CCDC169-SOHLH2 readthrough) and SOHLH2 (spermatogenesis and oogenesis specific basic helix-loop-helix 2). PHENOTYPE: Homozygous inactivation of this gene leads to female and male infertility due to defects in early oocyte and spermatogonial differentiation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
