| Primary Identifier | MGI:1916477 | Organism | mouse, laboratory |
| Chromosome | 3 | NCBI Gene Number | 69227 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable thioredoxin-disulfide reductase (NADPH) activity. Involved in cell redox homeostasis. Acts upstream of or within insulin secretion involved in cellular response to glucose stimulus and pancreas development. Located in endoplasmic reticulum. Orthologous to human SELENOT (selenoprotein T). PHENOTYPE: Mice homozygous for a conditional allele activated in beta cells exhibit impaired glucose tolerance, increased circulating glucose levels, decreased circulating insulin levels, decreased insulin secretion and an increase in smaller islets. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
