| Primary Identifier | MGI:1928396 | Organism | mouse, laboratory |
| Chromosome | 3 | NCBI Gene Number | 56426 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable protein homodimerization activity and protein kinase binding activity. Acts upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in Golgi membrane; cell periphery; and cytosol. Predicted to be part of FAR/SIN/STRIPAK complex. Is expressed in several structures, including cardiovascular system; central nervous system; gonad; gut; and retina layer. Used to study cerebral cavernous malformation 3. Human ortholog(s) of this gene implicated in cerebral cavernous malformation 3. Orthologous to human PDCD10 (programmed cell death 10). PHENOTYPE: Homozygous knockout is embryonic lethal due to impaired hematopoeisis, vasculogenesis, and abnormal heart morphology. Conditional knockout in myeloids increases degranulation of, and exocytosis by, neutrophils. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
