| Primary Identifier | MGI:95809 | Organism | mouse, laboratory |
| Chromosome | 3 | NCBI Gene Number | 14800 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables extracellularly glutamate-gated ion channel activity; glutamate-gated receptor activity; and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Acts upstream of or within chemical synaptic transmission. Located in several cellular components, including perisynaptic space; postsynaptic membrane; and synaptic vesicle membrane. Part of AMPA glutamate receptor complex. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic density membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; liver and biliary system; and sensory organ. Orthologous to human GRIA2 (glutamate ionotropic receptor AMPA type subunit 2). PHENOTYPE: Homozygotes for targeted null mutations exhibit epilepsy, deficient dendritic architecture, altered exploratory behavior, impaired motor and learning performance, and increased mortality. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
