Primary Identifier | MGI:3645057 | Organism | mouse, laboratory |
Chromosome | 3 | NCBI Gene Number | 633285 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables RNA binding activity. Involved in several processes, including cell cycle switching, mitotic to meiotic cell cycle; meiotic nuclear division; and spermatid differentiation. Acts upstream of or within mRNA stabilization and trophectodermal cell differentiation. Located in cytoplasm and nucleus. Is expressed in central nervous system; craniocervical region bone; dorsal root ganglion; lung; and rib. Orthologous to human RBM46 (RNA binding motif protein 46). PHENOTYPE: Mice with a homozygous frameshifting deletion between exons 2-3 exhibit infertility, with absence of oocytes, small testes and seminiferous tubules containing only Sertoli cells and few undifferentiated spermatogonia. [provided by MGI curators] |