| Primary Identifier | MGI:107675 | Organism | mouse, laboratory |
| Chromosome | 3 | Mgi Type | polymorphic pseudogene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable several functions, including histone binding activity; lipid antigen binding activity; and lipopeptide binding activity. Acts upstream of or within positive regulation of NK T cell activation; positive regulation of T cell mediated cytotoxicity; and positive regulation of cytokine production. Located in external side of plasma membrane. Is expressed in brain ventricular layer; craniocervical region bone; and pons mantle layer. Human ortholog(s) of this gene implicated in pulmonary tuberculosis. Orthologous to human CD1D (CD1d molecule). PHENOTYPE: Homozygotes for a targeted null mutation ablating both Cd1d1 and Cd1d2 exhibit very few NK1.1-bearing T cells and an impaired interleukin 4 (IL4) response upon systemic T cell activation. Such mice are phenotypically similar to mutants lacking only Cd1d1. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
