| Primary Identifier | MGI:1916703 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 69453 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Enables serine-type endopeptidase activity. Involved in proteolysis. Acts upstream of or within camera-type eye development. Located in endoplasmic reticulum. Is expressed in nervous system and visual system. Used to study angle-closure glaucoma; isolated microphthalmia 6; and nanophthalmos. Human ortholog(s) of this gene implicated in isolated microphthalmia 6. Orthologous to human PRSS56 (serine protease 56). PHENOTYPE: Mice homozygous for an ENU induced mutation show increased intraocular pressure, variable decreases in eye axial length, and narrow iridocorneal angles. Homozygous mice model angle-closure glaucoma. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
