| Primary Identifier | MGI:108053 | Organism | mouse, laboratory |
| Chromosome | 3 | NCBI Gene Number | 19769 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables GTP binding activity. Predicted to be involved in Ras protein signal transduction. Located in plasma membrane. Is expressed in Meckel's cartilage; bone; hip; liver; and rib. Used to study Noonan syndrome 8. Human ortholog(s) of this gene implicated in Noonan syndrome; Noonan syndrome 8; RASopathy; and hepatocellular carcinoma. Orthologous to human RIT1 (Ras like without CAAX 1). PHENOTYPE: Mice homozygous for a knock-out allele produce embryonic fibroblasts that exhibit increased cellular sensitivity to hydrogen peroxide. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
