Primary Identifier | MGI:1333882 | Organism | mouse, laboratory |
Chromosome | 3 | NCBI Gene Number | 11490 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable SH3 domain binding activity; metalloendopeptidase activity; and signaling receptor binding activity. Acts upstream of or within cardiac epithelial to mesenchymal transition. Located in extracellular space. Is expressed in atrioventricular valve; embryo; and semilunar valve. Orthologous to human ADAM15 (ADAM metallopeptidase domain 15). PHENOTYPE: Homozygous mutant mice develop normally and exhibit normal angiogenesis, but show a resistance to pathological neovascularization. [provided by MGI curators] |