Primary Identifier | MGI:1339468 | Organism | mouse, laboratory |
Chromosome | 3 | NCBI Gene Number | 20194 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable several functions, including calcium-dependent protein binding activity; protein homodimerization activity; and transmembrane transporter binding activity. Involved in mRNA transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; and regulation of neurogenesis. Located in cell surface and plasma membrane. Part of RNA polymerase II transcription regulator complex and plasma membrane protein complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart and pericardium; and sensory organ. Orthologous to human S100A10 (S100 calcium binding protein A10). PHENOTYPE: Mice homozygous for a knock-out allele display a depression-like phenotype, decreased responsiveness to 5-HT1B receptor agonists, and reduced behavioral reactions to an antidepressant. [provided by MGI curators] |