| Primary Identifier | MGI:1917019 | Organism | mouse, laboratory |
| Chromosome | 3 | NCBI Gene Number | 69769 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Acts upstream of or within negative regulation of T cell activation and negative regulation of inflammatory response. Located in cytoplasm. Is expressed in cerebral cortex subventricular zone and cerebral cortex ventricular layer. Orthologous to human TNFAIP8L2 (TNF alpha induced protein 8 like 2). PHENOTYPE: About 50% of mice homozygous for a null allele die prematurely of a chronic disease characterized by weight loss, splenomegaly, leukocytosis, and multiorgan inflammation; mutants are hypersensitive to septic shock while cells are hyperresponsive to Toll-like receptor and T cell receptor activation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
