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Protein Coding Gene : Cers2 ceramide synthase 2
Primary Identifier  MGI:1924143 Organism  mouse, laboratory
Chromosome  3 NCBI Gene Number  76893
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Enables sphingosine N-acyltransferase activity. Involved in ceramide biosynthetic process and regulation of lipid metabolic process. Acts upstream of or within sphingolipid biosynthetic process. Predicted to be located in endoplasmic reticulum. Is expressed in cerebral cortex; limb; liver; neural tube; and skin. Orthologous to human CERS2 (ceramide synthase 2).
PHENOTYPE: Mice homozygous for a gene trapped allele exhibit abnormal ceramide species and myelin sheath defects and develop hepatocellular carcinoma. [provided by MGI curators]
  • synonyms:
  • Lass2,
  • CerS2,
  • Cers2,
  • AI225939,
  • RIKEN cDNA 0610013I17 gene,
  • ceramide synthase 2,
  • Trh3,
  • LAG1 homolog, ceramide synthase 2,
  • 0610013I17Rik,
  • expressed sequence AI225939,
  • MGI:2139649
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2 Involved In Mutations

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0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

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4 Pathways

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Phenotype

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Disease

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