Primary Identifier | MGI:1924828 | Organism | mouse, laboratory |
Chromosome | 3 | NCBI Gene Number | 77578 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables beta-catenin binding activity. Acts upstream of or within several processes, including canonical Wnt signaling pathway; myotube differentiation involved in skeletal muscle regeneration; and skeletal muscle cell differentiation. Located in cis-Golgi network; nucleus; and sarcoplasm. Is expressed in several structures, including brain; eye; head surface ectoderm; metanephros; and thymus primordium. Orthologous to human BCL9 (BCL9 transcription coactivator). PHENOTYPE: Mice carrying homozygous floxed Bcl9 and Bcl9l alleles, inactivated in muscle cells, exhibit impaired muscle regeneration due to increased apoptosis. [provided by MGI curators] |