| Primary Identifier | MGI:3039619 | Organism | mouse, laboratory |
| Chromosome | 3 | NCBI Gene Number | 242122 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables signaling receptor binding activity. Acts upstream of or within positive regulation of interleukin-2 production; regulation of T cell activation; and response to protozoan. Located in external side of plasma membrane. Is expressed in several structures, including hemolymphoid system gland; liver; lung; male reproductive gland or organ; and pancreas. Orthologous to human VTCN1 (V-set domain containing T cell activation inhibitor 1). PHENOTYPE: Mice homozygous for this mutation display stronger Th1 responses upon parasitic infection by L. major including reduced footpad swelling and lower parasite burden compared to controls. Responses to other Th1-driven immune responses are normal. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
