| Primary Identifier | MGI:107170 | Organism | mouse, laboratory |
| Chromosome | 3 | NCBI Gene Number | 19260 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables SH3 domain binding activity; kinase binding activity; and protein tyrosine phosphatase activity. Involved in several processes, including dephosphorylation; regulation of cytokine production; and regulation of intracellular signal transduction. Acts upstream of or within T cell differentiation and T cell receptor signaling pathway. Located in cytoplasm; cytoplasmic side of plasma membrane; and nucleus. Is expressed in dorsal root ganglion; peripheral nervous system; and thymus primordium. Human ortholog(s) of this gene implicated in several diseases, including Addison's disease; Meniere's disease; autoimmune disease (multiple); graft-versus-host disease; and pulmonary tuberculosis. Orthologous to human PTPN22 (protein tyrosine phosphatase non-receptor type 22). PHENOTYPE: Homozygous null mice display antigen dependent increases in T cell proliferation and cytokine production, enlarged spleens and lymph nodes, increased spontaneous germinal center formation, increased B cell numbers, and increased serum IgG and IgE levels. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
