| Primary Identifier | MGI:2443718 | Organism | mouse, laboratory |
| Chromosome | 3 | NCBI Gene Number | 269473 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables signaling receptor binding activity. Acts upstream of or within several processes, including negative regulation of axon regeneration; negative regulation of membrane protein ectodomain proteolysis; and positive regulation of protein localization to cell surface. Located in growth cone; intracellular vesicle; and membrane. Is expressed in several structures, including branchial arch; central nervous system; eye; inner ear; and nasal pit. Human ortholog(s) of this gene implicated in urofacial syndrome. Orthologous to human LRIG2 (leucine rich repeats and immunoglobulin like domains 2). PHENOTYPE: Mice homozygous for a knock-out allele exhibit reduced susceptibility to PDGFB-induced glioma and premature death due to illness with reduced body weight, letahrgy, hackled fur, crouched posture and increased inflammatory response. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
