| Primary Identifier | MGI:1917715 | Organism | mouse, laboratory |
| Chromosome | 3 | NCBI Gene Number | 70465 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables ubiquitin-like ligase-substrate adaptor activity. Involved in protein polyubiquitination and ubiquitin-dependent protein catabolic process. Acts upstream of or within several processes, including negative regulation of epithelial cell proliferation involved in prostate gland development; regulation of transcription by RNA polymerase II; and secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development. Part of Cul4B-RING E3 ubiquitin ligase complex. Is expressed in genitourinary system. Orthologous to human WDR77 (WD repeat domain 77). PHENOTYPE: Mice homozygous for a knock-out allele die prior to E8.5 for unknown reasons. Heterozygotes develop multifocal hyperplasia in the dorsal prostate; however, no prostate tumors are detected up to 12 months of age. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
