| Primary Identifier | MGI:1923670 | Organism | mouse, laboratory |
| Chromosome | 3 | NCBI Gene Number | 100503311 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables cytoskeletal protein binding activity and enzyme binding activity. Involved in regulation of cell projection organization. Acts upstream of or within with a positive effect on cilium organization. Acts upstream of or within embryonic heart tube left/right pattern formation. Located in ciliary basal body; nucleus; and trans-Golgi network. Is expressed in several structures, including brain ventricle and choroid plexus; embryo ectoderm; nasal cavity epithelium; testis; and upper jaw. Orthologous to human CIMAP3 (ciliary microtubule associated protein 3). PHENOTYPE: Heterozygous null embryos generated by tetraploid complementation display embryonic lethality with double outlet heart right ventricle, duplicated cilia and defects in cilia disassembly. A conditional allele activated in limb bub cultures doesn't interfere with cilia development. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
