| Primary Identifier | MGI:2443205 | Organism | mouse, laboratory |
| Chromosome | 3 | NCBI Gene Number | 229700 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables RNA binding activity. Involved in regulation of alternative mRNA splicing, via spliceosome and thrombopoietin-mediated signaling pathway. Acts upstream of or within several processes, including circulatory system development; regulation of transcription by RNA polymerase II; and spleen development. Located in nucleus. Is expressed in several structures, including brain; olfactory epithelium; retina; thymus; and trophectoderm. Orthologous to human RBM15 (RNA binding motif protein 15). PHENOTYPE: Mice homozygous for a knock-out allele exhibit embryonic lethality around E9.5. Mice homozygous for a floxed allele activate in hematopoietic cells exhibit increased megakaryocyte cell number, long-term hematopoietic stem cells, and red pulp as well as decreased B cells and leukocytes. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
