| Primary Identifier | MGI:88381 | Organism | mouse, laboratory |
| Chromosome | 3 | NCBI Gene Number | 14066 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable cytokine receptor activity; phospholipid binding activity; and protease binding activity. Predicted to contribute to serine-type endopeptidase activity. Predicted to be involved in several processes, including activation of plasma proteins involved in acute inflammatory response; positive regulation of cysteine-type endopeptidase activity; and positive regulation of signal transduction. Predicted to act upstream of or within positive regulation of interleukin-8 production. Predicted to be located in cell surface; collagen-containing extracellular matrix; and extracellular space. Predicted to be part of serine-type peptidase complex. Predicted to be active in plasma membrane. Is expressed in several structures, including central nervous system; egg cylinder; genitourinary system; gut; and respiratory system. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; COVID-19; disseminated intravascular coagulation; and von Willebrand's disease. Orthologous to human F3 (coagulation factor III, tissue factor). PHENOTYPE: Homozygotes for targeted null mutations exhibit impaired blood vessel development, retarded growth, and, in most cases, midgestational lethality. On a mixed background, some mutants survive to birth and appear to be normal. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
