Primary Identifier | MGI:2443818 | Organism | mouse, laboratory |
Chromosome | 3 | NCBI Gene Number | 214137 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable GTPase activator activity and PDZ domain binding activity. Predicted to be involved in negative regulation of small GTPase mediated signal transduction. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm. Is expressed in several structures, including 1st branchial arch; alimentary system epithelium; facial prominence; meninges; and skin. Orthologous to human ARHGAP29 (Rho GTPase activating protein 29). PHENOTYPE: Homozygous inactivation of this gene results in complete embryonic lethality between implantation and placentation. Heterozygotes show abnormal oral epithelial adhesions during embryogenesis. [provided by MGI curators] |