| Primary Identifier | MGI:95478 | Organism | mouse, laboratory |
| Chromosome | 3 | NCBI Gene Number | 14079 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable long-chain fatty acid binding activity and long-chain fatty acid transmembrane transporter activity. Predicted to be involved in fatty acid metabolic process; intestinal absorption; and long-chain fatty acid transport. Predicted to be located in apical cortex and microvillus. Predicted to be active in cytosol and nucleus. Is expressed in embryo endoderm; gut; liver and biliary system; and skeletal muscle. Human ortholog(s) of this gene implicated in alcoholic liver cirrhosis; carotid stenosis; coronary artery disease; end stage renal disease; and obesity. Orthologous to human FABP2 (fatty acid binding protein 2). PHENOTYPE: Male mutant mice exhibit increased body weight, hyperinsulinemia, increased leptin levels on a high fat diet and have elevated circulating levels of triglycerides. Female mutant mice exhibit a decreased body weight on a high fat diet compared to controls. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
